RELAÇÃO EXISTENTE ENTRE BIOFILMES BACTERIANOS, QUORUM SENSING, INFECÇÕES E RESISTÊNCIA A ANTIBIÓTICOS: UMA REVISÃO BIBLIOGRÁFICA

Neila Batista Damaceno, Luciana Ramalho Farias

Resumo


Resumo

Este trabalho aborda a relação do quorum sensing na formação do biofilme bacteriano. O quorum sensing é um mecanismo de comunicação bacteriano, envolvido na expressão de fatores de virulência e formação de biofilme. Desse modo, impedir o funcionamento do quorum sensing é uma estratégia para contenção do biofilme. O biofilme é descrito como um aglomerado de células bacterianas ancoradas irreversivelmente a uma superfície inerte ou viva. Quando formado, o biofilme ocasiona/agrava infecções, e devido a sua estrutura tridimensional, dificulta o tratamento com antimicrobianos, promovendo a resistência aos mesmos.

Palavras-chave: Biofilme; resistência; quorum sensing; infecção.

 

Abstract

This work addresses the relationship of quorum sensing in the formation of bacterial biofilms. The quorum sensing is a mechanims of bacterial communication, envolving the expression of virulence factors and the biofilm formation. Therefore, hindering the operation of quorum sensing is an strategy to control biofilm. The biofilm is described as a cell pellet bacteria irreversibly anchored to an inert or living surface. Once formed, biofilms cause/aggravate infections, and also, due to its three-dimensional structure, it hinders the antimicrobial treatment, promoting antimicrobial resistance.

Keywords: Biofilm; resistance; quorum sensing; infections.

 

figshare DOI: 10.6084/m9.figshare.9788858


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Referências


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Revista Brasileira de Pesquisa em Ciências da Saúde - RBPeCS - ISSN: 2446-5577


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