BACULOVÍRUS: UM VÍRUS VERSÁTIL USADO NO CONTROLE BIOLÓGICO E COMO VETOR DE EXPRESSÃO DE PROTEÍNAS HETERÓLOGAS APLICADAS NA SAÚDE HUMANA
Resumo
RESUMO
Objetivo: revisar a história, morfologia, o ciclo de vida de infecção do baculovírus no inseto hospedeiro e finalmente as aplicações de expressão mediada por baculovírus no controle de pragas e terapia genética em células de mamíferos. Fonte de dados: o desenvolvimento desse trabalho consistiu em uma revisão de literatura. As bases de dados utilizadas foram: SciELO e PubMed, onde foram feitas buscas por artigos e livros referentes ao baculovírus com enfoque na sua morfologia, ciclo de replicação e aplicações biotecnológicas na área de saúde. Adotou-se como critério inicial para seleção a utilização das palavras-chaves “baculovirus”, “baculovirus life cycle”, “gene therapy”, “baculovirus applications” e “aplicações biotecnológicas”. Resultados: nas últimas décadas, com o avanço da biologia molecular, os baculovírus evoluíram de um simples vírus de insetos, usados até então apenas no controle biológico de pragas agrícolas, para ferramentas biotecnológicas versáteis, que podem ser usadas para infectar células de insetos e também transduzir células de mamíferos para a expressão de uma grande variedade de proteínas heterólogas. Conclusão: o baculovírus surgiu como um novo vetor para a entrega de genes. Além disso, o uso da transferência de genes mediada por baculovírus foi consideravelmente expandida para triagem de medicamentos, exibição de genes eucarióticos, terapia de câncer, engenharia de tecidos, vacinas e outras aplicações.
ABSTRACT
Objective: to review the history, morphology, life cycle of baculovirus infection in the host insect, and finally as applications of baculovirus-mediated expression in pest control and gene therapy in mammalian cells. Data source: the databases used were: SciELO and PubMed, where were searched for articles and books related to baculovirus focusing on its morphology, replication cycle, and biotechnological applications in health subjects. It was adopted as initial criteria for selecting the keywords: “baculovirus”, “baculovirus life cycle”, “gene therapy”, “baculovirus applications” and “biotechnological applications”. Results: in recent decades, with the advancement of molecular biology, baculovirus has evolved from a simple insect virus used only in biological control of agricultural pests, to versatile biotechnological tools that can be used to infect insect cells and also transducing mammalian cells for the expression of a wide variety of heterologous proteins. Conclusion: therefore, baculovirus has emerged as a new vector for gene delivery. Also, the use of baculovirus-mediated gene transfer has been considerably expanded for drug screening, eukaryotic gene display, cancer therapy, tissue engineering, vaccines, and other applications.
Figshare DOI: 10.6084/m9.figshare.12838052
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