ASPECTOS CLÍNICOS, PRÉ-, PERI- E PÓS-NATAIS E GENÉTICA FAMILIAR EM HIPOMINERALIZAÇÃO MOLAR-INCISIVO – RELATO DE CASO

Kelly da Silva Rodrigues, Maysa Ferreira Veiga Sarmento, Ana Luiza Meneguci Moreira Franco, Flávia Martinez Carvalho, Fernanda Mafei Felix Silva, Marcela Baraúna Magno

Resumo


A Hipomineralização Molar Incisivo (HMI) consiste num defeito qualitativo do esmalte dental caracterizado por lesões que variam de cor branca a marrom e que acomete, principalmente, os primeiros molares e incisivos permanentes. Sua etiologia está relacionada a fatores genéticos e ambientais. O método de estudo de associação em que se utiliza o polimorfismo como marcador para localização de genes candidatos a doenças tem sido comumente empregado na busca de evidências que relacionam a HMI a fatores genéticos. O objetivo deste trabalho é relatar aspectos clínicos, pré, peri e pós-natais de uma paciente de 21 anos diagnosticada com HMI, além de realizar avaliação clínica e genética (polimorfismos no gene ENAM) familiar. Foi realizado avaliação clínica dos pais e coleta de material biológico (saliva) para avaliação e análise do DNA familiar. O pai foi diagnosticado com HMI enquanto a mãe não. As amostras coletadas foram analisadas em PCR em tempo real, sendo genotipado o polimorfismo rs7664896 (C>G) localizado no gene ENAM. A paciente apresentou genótipo CG com herança da condição pelo pai. A paciente apresentou genótipo CG com herança da condição pelo pai. Pode-se inferir a interação entre aspectos ambientais e genéticos na etiologia da HMI da paciente do presente relato. Estudos com amostras maiores, de diferentes etnias e com avaliação de diferentes genes são estimulados para aumentar a robustez das evidências científicas.

Palavras-chave


Hipomineralização molar; Esmalte dental; Teste genético; Etiologia

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Referências


Alaluusua S. Aetiology of Molar-Incisor Hypomineralisation: A systematic review. Eur Arch Paediatr Dent. 2010 Apr;11(2):53-8.

Americano GC, Jacobsen PE, Soviero VM, Haubek D. A systematic review on the association between molar incisor hypomineralization and dental caries. Int J Paediatr Dent. 2017 Jan;27(1):11-21

Bussaneli DG, Restrepo M, Fragelli CMB, Santos-Pinto L, Jeremias F, Cordeiro RCL, et al. Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization. Caries Res. 2019;53(2):217-227.

Chawla N, Messer LB, Silva M. Clinical studies on molar-incisor-hypomineralisation part 2: development of a severity index. Eur Arch Paediatr Dent. 2008 Dec;9(4):191-9.

Clarkson J. Review of terminology, classifications, and indices of developmental defects of enamel. Adv Dent Res. 1989 Sep;3(2):104-9.

Crombie F, Manton D, Kilpatrick N. Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent. 2009 Mar;19(2):73-83.

Domingos PAS, Donato HA, Nonato CN, Souza EO, Silva VJ. Hipomineralização Molar- Incisivo: revisão de literatura. J Res Dent. 2019;7(1):8-12

Elfrink ME, Ghanim A, Manton DJ, Weerheijm KL. Standardised studies on Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM): a need. Eur Arch Paediatr Dent. 2015 Jun;16(3):247-55

Farah RA, Swain MV, Drummond BK, Cook R, Atieh M. Mineral density of hypomineralised enamel. J Dent. 2010 Jan;38(1):50-8

Fernandes AS, Mesquita P, Vinhas L. Hipomineralização incisivo-molar: uma revisão da literatura. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial. Out 2012;53(4):258-62

Fincham AG, Moradian-Oldak J, Simmer JP. The structural biology of the developing dental enamel matrix. J Struct Biol. 1999 Jun 30;126(3):270-99

Fukae M, Tanabe T, Uchida T, Yamakoshi Y, Shimizu M. Enamelins in the newly formed bovine enamel. Calcif Tissue Int. 1993 Oct;53(4):257-61

Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D; CARE Group*. The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development. Glob Adv Health Med. 2013 Sep;2(5):38-43.

Garot E, Rouas P, Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent. 2022 Feb;23(1):23-38

Garot E, Denis A, Delbos Y, Manton D, Silva M, Rouas P. Are hypomineralised lesions on second primary molars (HSPM) a predictive sign of molar incisor hypomineralisation (MIH)? A systematic review and a meta-analysis. J Dent. 2018 May; 72:8-13

Goldstein DB, Cavalleri GL. Genomics: understanding human diversity. Nature. 2005 Oct 27;437(7063):1241-2

Ghanim A, Morgan M, Mariño R, Bailey D, Manton D. Molar-incisor hypomineralisation: prevalence and defect characteristics in Iraqi children. Int J Paediatr Dent. 2011 Nov;21(6):413-21

Ghanim A, Elfrink M, Weerheijm K, Mariño R, Manton D. A practical method for use in epidemiological studies on enamel hypomineralisation. Eur Arch Paediatr Dent. 2015 Jun;16(3):235-46.

Guedes-Pinto AC. Odontopediatria. 9a ed. São Paulo: Santos; 2016. 832 p.

Gutiérrez S, Torres D, Briceño I, Gómez AM, Baquero E. Clinical and molecular analysis of the enamelin gene ENAM in Colombian families with autosomal dominant amelogenesis imperfecta. Genet Mol Biol 2012;35:557–66

Hong L, Levy SM, Warren JJ, Dawson DV, Bergus GR, Wefel JS. Association of amoxicillin use during early childhood with developmental tooth enamel defects. Arch Pediatr Adolesc Med. 2005 Oct;159(10):943-8

Hubbard MJ, Mangum JE, Perez VA, Williams R. A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model. Front Physiol. 2021 Dec 21;12:802833

Jeremias F, Koruyucu M, Küchler EC, Bayram M, Tuna EB, Deeley K, et al. Genes expressed in dental enamel development are associated with molar-incisor hypomineralization. Arch Oral Biol. 2013 Oct;58(10):1434-42.

Jeremias F, Pierri RA, Souza JF, Fragelli CM, Restrepo M, Finoti LS, et al. Family-Based Genetic Association for Molar-Incisor Hypomineralization. Caries Res. 2016;50(3):310-8

Jeremias F, Bussaneli DG, Restrepo M, Pierri RAG, Souza JF de, Fragelli CMB, et al. Inheritance pattern of molar-incisor hypomineralization. Braz Oral Res 2021;35

Laisi S, Ess A, Sahlberg C, Arvio P, Lukinmaa PL, Alaluusua S. Amoxicillin may cause molar incisor hypomineralization. J Dent Res. 2009 Feb;88(2):132-6

Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022 Feb;23(1):3-21

Mast P, Rodrigueztapia MT, Daeniker L, Krejci I. Understanding MIH: definition, epidemiology, differential diagnosis and new treatment guidelines. Eur J Paediatr Dent. 2013 Sep;14(3):204-8.

Ozgül BM, Saat S, Sönmez H, Oz FT. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. J Clin Pediatr Dent. 2013 Winter;38(2):101-5.

Pinheiro SF, Cunha MJ, Amorim FC, Lopes MF, Pinheiro IV. Amelogênese imperfeita em paciente nefropata: relato de uma reabilitação oral conservadora. Rev. Gauch. Odontol. 2010;58(4):527-31.

Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M, et al. High-throughput genotyping with single nucleotide polymorphisms. Genome Res. 2001 Jul;11(7):1262-8.

Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr R, Luong VQ, et al. Dental enamel: genes define biomechanics. J Calif Dent Assoc. 2009 Dec;37(12):863-8

Robinson C. Enamel maturation: a brief background with implications for some enamel dysplasias. Front Physiol. 2014 Oct 8; 5:388.

Rodd HD, Abdul-Karim A, Yesudian G, O'Mahony J, Marshman Z. Seeking children's perspectives in the management of visible enamel defects. Int J Paediatr Dent. 2011 Mar;21(2):89-95.

Schork NJ, Fallin D, Lanchbury JS. Single nucleotide polymorphisms and the future of genetic epidemiology. Clin Genet. 2000 Oct;58(4):250-64.

Silva CM, Zuanon AC, Jeremias F, Santos PL. Hipomineralização molar incisivo (HMI) e hipoplasia de esmalte: avaliação clínica e microscópica (MEV). Rev. Odontol. UNESP. 2008;37(2):97

Silva FM, Magno MB, Neves AB, Coqueiro RD, Costa MD, Maia LC, et al. Aesthetic perceptions and social judgments about different enamel opacities. Braz. Oral Res. 2020;34.

Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization - A systematic review. Community Dent Oral Epidemiol. 2016 Aug;44(4):342-53.

Smith MM, Coates MI. Evolutionary origins of the vertebrate dentition: phylogenetic patterns and developmental evolution. Eur J Oral Sci. 1998 Jan;106 Suppl 1:482-500.

Souza JB, Rodrigues PC, Lopes LG. Enamel hipoplasia: aesthetic restorative treatment. ROBRAC. 2010;18(47):14-9

Spezzia S. Hipomineralização molar incisivo em odontopediatria: considerações gerais. J. Oral Investig. 2019;8(1):100-13.

Suga S. Enamel hypomineralization viewed from the pattern of progressive mineralization of human and monkey developing enamel. Adv Dent Res. 1989 Sep;3(2):188-98.

Teixeira RJPB, Andrade NS, Queiroz LCC, Mendes FM, Moura MS, Moura LFAD, et al. Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study. Int J Paediatr Dent. 2018 Mar;28(2):198-206.

Vieira AR, Kup E. On the Etiology of Molar-Incisor Hypomineralization. Caries Res. 2016;50(2):166-9

Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res. 2001 Sep-Oct;35(5):390-1.

Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update. 2004 Jan-Feb;31(1):9-12


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