Visão Fisioterapêutica sobre a Reabilitação da Paraplegia Através da Regeneração Funcional da Reconexão da Medula por Meio de Transplantes de Células Oec: Relato de Caso

Denise Elaine Oliveira Souza, Candice Rocha Seixas

Resumo


Resumo: Estudos mostram que as Células Olfativas Embainhadas (OEC) podem ser uma resposta para a reversão da paraplegia, pois há possibilidades regenerativas neurais associadas à fisioterapia. O corpo possui um sistema de inteligência complexo, controlado pelo cérebro e pela medula espinhal. Quando a medula espinhal é danificada, a capacidade de andar fica comprometida. Por meio do transplante de células OEC, pode ocorrer a reconexão na região lesionada. Objetivo: Nesta pesquisa clínico-qualitativa conheceremos o papel e a atuação da fisioterapia intensiva na reabilitação da paraplegia, por meio do método pioneiro do Dr. Raisman, que visa restaurar a força após lesão medular. Metodologia: Para esta formulação, foram selecionados artigos, além de uma entrevista semiestruturada com o paciente, após aprovação pelo Comitê de Ética Profissional. Discussão: Percebemos que programas fisioterapêuticos intensivos podem proporcionar excelentes respostas na recuperação motora e neurológica de pacientes submetidos a terapias restauradoras. O treinamento repetitivo e intenso foi benéfico ao primeiro paciente que recuperou a marcha. Conclusão: Entendemos que as células OEC são altamente especializadas em regeneração e podem superar o dano na medula espinhal. Embora o Projeto apresentado seja classificado como um projeto experimental, exigindo comprovação quantitativa, a importância de planos fisioterapêuticos intensivos é clara.

Palavras-chave: Lesão da medula espinhal, transplante celular, células OEC, neurorestaurador.      

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Abstract: Studies show that Olfactory Ensheathed Cells (OEC) may be an answer for reversing paraplegia, as there are neural regenerative possibilities associated with physiotherapy. The body has a complex intelligence system, controlled by the brain and spinal cord. When the spinal cord is damaged, the ability to walk is compromised. Through the transplantation of OEC cells, reconnection can occur in the injured region. Objective: In this clinical-qualitative research, we will learn about the role and performance of intensive physiotherapy in the rehabilitation of paraplegia, through Dr. Raisman's pioneering method, which aims to restore strength after spinal cord injury. Methodology: For this formulation, articles were selected, in addition to a semi-structured interview with the patient, after approval by the Professional Ethics Committee. Discussion: We realized that intensive physiotherapy programs can provide excellent responses in the motor and neurological recovery of patients undergoing restorative therapies. Repetitive and intense training was beneficial to the first patient who recovered walking. Conclusion: We understand that OEC cells are highly specialized in regeneration and can overcome the damage in the spinal cord. Although the presented Project is classified as an experimental project, requiring quantitative proof, the importance of intensive physiotherapeutic plans is clear.

Keywords: Spinal cord injury, cell transplantation, OEC cells, neurorestorative.

 

DOI: 10.5281/zenodo.15132366


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Referências


Li Y, Tabakow P, Li D, Huang H. Commemorating Geoffrey Raisman: a great neuroscientist and one of the founders of neurorestoratology and the IANR. Journal of Neurorestoratology. 2018 Mar;Volume 6:29–39. https://doi.org/10.2147/JN.S159088.

Koblańska M. Zapaliliśmy zielone światło Rozmowa z prof. Włodzimierzem Jarmundowiczem z Uniwersyteckiego Szpitala Klinicznego we Wrocławiu, członkiem zespołu, który uhonorowaliśmy Nagrodą Specjalną za udany przeszczep komórek rdzenia kręgowego. Menedżer Zdrowia. 2014;(10):38-41. Available at: << https://www.termedia.pl/Zapalilismy-zielone-swiatlo-Rozmowa-z-prof-Wlodzimierzem-Jarmundowiczem-z-Uniwersyteckiego-Szpitala-Klinicznego-we-Wroclawiu-czlonkiem-zespolu-ktory-uhonorowalismy-Nagroda-Specjalna-za-udany-przeszcze,12,24394,1,0.html >> Accessed on 07/13/2022.

Machado A., Machado L. H: Neuroanatomia Funcional, 3ª edição. Editora Atheneu, São Paulo, 2014.

Khankan RR, Griffis KG, Haggerty-Skeans JR, Zhong H, Roy RR, Edgerton VR, et al. Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration. Journal of Neuroscience [Internet]. 2016 Jun 8;36(23):6269–86. Available from: https://www.jneurosci.org/content/36/23/6269.

Phedy P, Djaja YP, Gatam L, Kusnadi Y, Wirawan RP, Tobing IMS, Subakir N, Mappalilu A, Prawira MA, Yauwenas R, Gatam AR. Motoric Recovery After Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Chronic Spinal Cord Injury: A Case Report. Am J Case Rep 2019 Sep 2;20:1299-1304. doi: 10.12659/AJCR.917624. PMID: 31474745.

Li M, Zhu Q, Liu J. Olfactory ensheathing cells in facial nerve regeneration. Brazilian Journal of Otorhinolaryngology. 2020 Sep 1;86(5):525–33. https://doi.org/10.1016/j.bjorl.2018.07.006.

Yao R, Murtaza M, Velasquez JT, Todorovic M, Rayfield A, Ekberg J, et al. Olfactory Ensheathing Cells for Spinal Cord Injury. Cell Transplantation [Internet]. 2018 Jun 1 [cited 2020 Dec 15];27(6):879–89. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050914/. DOI:10.1177/0963689718779353.

Tabakow P, Jarmundowicz W, Czapiga B, Fortuna W, Miedzybrodzki R, Czyz M, et al. Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury. Cell Transplantation. 2013 Sep;22(9):1591–612.. DOI:10.3727/096368912X663532.

Tabakow P, Raisman G, Fortuna W, Czyz M, Huber J, Li D, et al. Functional Regeneration of Supraspinal Connections in a Patient with Transected Spinal Cord following Transplantation of Bulbar Olfactory Ensheathing Cells with Peripheral Nerve Bridging. Cell Transplantation. 2014 Dec;23(12):1631–55. DOI:10.3727/096368914X685131.

Hongyun H, Wise Young, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari Shanker Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, Shiqing Feng, Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019), Journal of Orthopedic Translation, Volume 20, 2020, Pages 14-24, ISSN 2214-031X, https://doi.org/10.1016/j.jot.2019.10.006.

Fidyka, D. Physiotherapeutic Look at the Rehabilitation of Paraplegia Through Functional Regeneration of Medullary Reconnection Through Cell Oec’s Transplants. [Interview given to] Denise Souza, Bahia, Oct.2023.


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Revista Brasileira de Pesquisa em Ciências da Saúde - RBPeCS - ISSN: 2446-5577


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