Development, delivery strategies, cell uptake and efficacy of nanoparticles and their role for leishmaniasis - a review

Resumo

Abstract: Nanoparticles (NPs) have been considered one of the most promising strategies for the treatment of several diseases. There are different types of nanoparticles available, designed to perform specific functions according to the disease model, the type of tissue or target cell and the response you want to achieve. It is known that to synthesize a nanoparticle, there are many protocols developed by researchers according to the area of interest. After the synthesis process, this material needs to undergo different types of physical-chemical characterization to attest its properties, such as surface charge, diameter, chemical composition, electrical conductivity, and stability. The literature has already provided us with a lot of information about how these parameters bring us the "ideal nanoparticle" for each test, informing the appropriate size and the interference of the surface charge for cell uptake, for example. In this review, we will show what is most recent about these parameters, the processes of cell uptake and some NPs that have been tested against leishmaniasis and its main role in target tissues and cells.

Keyword: nanoparticles,zeta potential, diameter,cell uptake, macrophages, leishmaniasis.